Corrigendum: Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?

Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?

Safety pharmacology aims to predict rare side effects of new drugs. We explored whether rare pro-arrhythmic effects could be linked to the variability of the effects of these drugs on ion currents and whether taking into consideration this variability in computational models could help to better detect and predict cardiac side effects. For this purpose, we evaluated how intra- and inter-individ...

Inter-individual Variability of Coumarin 7-hydroxylation (CYP2A6 activity) in an Iranian Population

Pharmacokinetic/Pharmacodynamic (PK/PD) Relationship-based Approach to Understand the Variability of Central Neurological Effects of Ethanol

Pharmacokinetic/pharmacodynamic (PK/PD) relationships describe the quantitative relationships between the drug-induced effects and the concurrent corresponding drug concentrations in an individual. Since a long time, rough qualitative relationships have been described between neurological presentation and plasma ethanol concentration in acute ethanol ingestion. However, to date, precise quantit...

Professional errors and patient safety in intensive cardiac care unit:

Abstract Introduction: Use of progressive technology, clinical skills and caring methods appropriate to critical situations of patient in intensive Cardiac Care Unit is probably related to professional errors and disorder in patient safety. There is a little data about this subject. Objective: The aim of this study was to explore professional errors and patient safety in Cardiac Care Unit. Meth...

Heart Rate Variability Classification using Support Vector Machine and Genetic Algorithm

Background: Electrocardiogram (ECG) is defined as an electrical signal, which represents cardiac activity. Heart rate variability (HRV) as the variation of interval between two consecutive heartbeats represents the balance between the sympathetic and parasympathetic branches of the autonomic nervous system.Objective: In this study, we aimed to evaluate the efficiency of discrete wavelet transfo...